Dermatopathology Services

Labcorp pathology offers a comprehensive menu of assays and services to aid in the diagnosis, prognosis, and monitoring of dermatological conditions. In addition, Labcorp pathology’s advanced immunohistochemistry staining techniques allow for tissue conservation on small samples.

Melanoma FISH

Labcorp pathology offers a melanoma FISH panel that can help dermatopathologists diagnose ambiguous skin lesions. This FISH panel consists of RREB1 (6p25), MYB (6q23), 6 centromere, and CCND1 (11q13) and can be useful in differentiating melanomas from benign nevi. The test is available as a stand-alone or can be ordered as a reflex test for lesions deemed ambiguous or suspicious for melanoma by our dermatopathologists.

BRAF Gene Mutation Analysis

In patients with malignant melanoma, a mutation in the BRAF gene has been found to significantly improve response rates to therapy using vemurafenib (Zelboraf®*). Labcorp pathology offers a BRAF mutation test that is approved by the FDA as a companion diagnostic.


*Zelboraf is a registered trademark of Genentech, Inc.


Labcorp pathology offers an extensive list of immunohistochemistry including:

  • Keratin markers for diagnosing carcinomas, including AE1/AE3, CK5/6, CK7, and CK20
  • Markers for diagnosing melanocytic lesions, including S-100 protein, Melan-A, HMB45, and MiTF
  • CD markers for diagnosing lymphoproliferative disorders, including CD3/20/30/4/5/7/8/10/43/45
  • Markers for diagnosing sarcomas including vimentin, desmin, and HHV-8

In situ hybridization and direct immunofluorescence

  • Human papillomavirus (HPV) testing by in situ hybridization (ISH) for low- and high-risk HPV subtyping
  • Direct immunofluorescence (DIF) test for immunobullous disorders and collagen vascular diseases